Phosphorylation of C-terminal tyrosine 526 in FUS impairs its nuclear import
نویسندگان
چکیده
منابع مشابه
Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import.
Aberrant cytoplasmic aggregation of FUS, which is caused by mutations primarily in the C-terminal nuclear localisation signal, is associated with 3% of cases of familial amyotrophic lateral sclerosis (ALS). FUS aggregates are also pathognomonic for 10% of all frontotemporal lobar degeneration (FTLD) cases; however, these cases are not associated with mutations in the gene encoding FUS. This sug...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2015
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.176602